Dr. Belury’s research interests are investigating the mechanisms of bioactive lipids in regulating insulin sensitivity in liver, adipose and muscle; and the role of energy balance in cancer prevention.
Education
- PhD, Biological Sciences, University of Texas, Austin, 1992
- BS, Nutrition, University of Texas, Austin, 1987
Research Interests
Research Summary
Our lab is chiefly interested in selective metabolic modulators in the diet. The compounds that we study include polyunsaturated fatty acids, isoflavones and metabolites derived from these dietary constituents. As signaling molecules and components of phospholipids, these molecules exert potent effects on mitochondrial and insulin-dependent energy metabolism and inflammatory pathways.
Goals include:
- Determine the impact of fatty acid moieties and isoflavones on whole body energy metabolism as regulated by interactions between adipose, liver and muscle tissues
- Elucidate mechanistic targets of dietary bioactives to impact mitochondrial functions
- Identify the pathogenesis of muscle atrophy related to aging, cognitive decline, sarcopenia and cancer cachexia
Models include:
- murine models
- cell culture models
- Randomized controlled trials
- observational clinical studies
Experience
- 2022 – present: Interim Chair, Department of Food Science and Technology, The Ohio State University, Columbus, OH
- 2002 – 2023: Carol S. Kennedy Endowed Professorship of Human Nutrition, The Ohio State University, Columbus, OH
- 2009 – Present: Adjunct Professor, Division of Environmental Health, College of Public Health, The Ohio State University, Columbus, OH
- 2004 – Present: Adjunct Professor, Division of Endocrinology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH
- 2002 – Present: Associate/ Full Professor, Human Nutrition, The Ohio State University, Columbus, OH
- 2000 – 2002: Associate Member, Department of Molecular Medicine, Northwest Hospital, Seattle, WA
- 1994 – 2000: Assistant/Associate Professor, Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana
- 1992 – 1994: Assistant Professor, Department of Health and Human Development, Montana State University, Bozeman, Montana
Honors
- 2022-2023: President of the American Society for Nutrition (ASN) (prior terms as Vice-President, Vice President-elect
- 2022: Ralph T. Holman Lifetime Achievement Award, American Oil Chemists’ Society
- 2014: Robert H. Herman Memorial Award for Outstanding Research, American Society of Nutrition (ASN), Presented at Experimental Biology, San Diego, CA
- 2012: Most Cited Paper [1] (ranked 17th) in 70-year history of Nutrition Reviews journal, International Life Sciences Institute (ILSI), Washington, DC ·
- 2011: Elected Fellow, American Association for the Advancement of Science (AAAS), Washington, DC
- 2011: Visiting Professorship, Taipei Medical University, Taipei, Taiwan
- 2003: Hot Paper [2], ESI Essential Scientific Indicators, Most Cited Paper for Agricultural Sciences for Third Quarter, Thomson Reuters
- 2000: E.L.R Stokstad Award for Outstanding Research, American Society for Nutritional Sciences (ASNS), Presented at Experimental Biology, April 16, 2000, San Diego, CA
- 1999: Outstanding Young Professional Award for 1999, Texas Exes in Human Ecology, University of Texas, Austin, TX
- 1993: Most Influential Teacher, College of Education, Health and Human Development, Montana State University, Bozeman, MT
- 1992: Pre-Doctoral Training Grant in Toxicology, NIEHS, NIH, University of Texas, Austin, TX
[1] Belury, MA. Conjugated dienoic linoleate: A unique chemoprotective polyunsaturated fatty acid. Nutr Rev 1995; 53: 83-89
[2] Belury, MA. Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annu Rev Nutr 2002; 22: 505-531
Selected Grants
Effects of Dietary Soybean Oil on Liver Fat, Body Composition and Cardiometabolic Disease Risk in Adults with NAFLD
Martha Belury, PI United Soybean Board, Soy Nutrition Institute
National Needs Fellowship: Multidisciplinary Training of Fellows in Food & Nutrition for Obesity & Cancer Prevention, USDA 2017-09503
Role: Martha Belury, PI
Remote Assessment of Cognition, Insulin Resistance and Omega-3 Fatty Acid Biomarkers in Obese Breast Cancer Survivors at Risk for Cognitive Impairment Tonya Orchard, PI
Role: Martha Belury, Co-I
Mediators of Pancreatic Cancer-Associated Cachexia, NIH/NCI CA R21 256409
Zobeida Cruz-Monserrate, PI
Role: Martha Belury, Co-I
Selected Publications
For Full Publication Access (Belury PubMed.gov)
Average Citations per Item 34.45
www.webofscience.com (9 May 2022)
Relative Citation Ratio (RCR), 196.07
NIH iCite (5 April 2021)
Peer-Reviewed Original Research Publications
- Snoke DB, Angelotti A, Borkowski K, Cole RM, Newman JW, Belury MA. Linoleate-Rich Safflower Oil Diet Increases Linoleate-Derived Bioactive Lipid Mediators in Plasma, and Brown and White Adipose Depots of Healthy Mice. Metabolites, 12: 743, doi: 10.3390/metabo12080743
- Conrad Z, Kowalski C, Dustin D, Johnson LK, McDowell A, Salesses M, Nance J, Belury MA. Quality of popular diet patterns in the United States: evaluating the effect of substitutions for foods high in added sugar, sodium, saturated fat, and refined grains. Curr Dev Nutr, in press
- Garden-Robinson J, Belury MA, Cawthon PM, Hilliard E, Houfek A, Rhee Y, Stastny S, McGrath R. Older American Women May Especially Benefit from Distributing and Consuming Protein for Decreasing Odds of Functional Limitations. J Gerontol Med Sci, under review
- Mitchell, AM, Kowalsky, JM, Belury, MA, Cole, RM, Christian, LM. Perceived social support predicts self-reported health behaviors and objective health indicators among pregnant women. J Behav Med 2022; 45: 589-602; DOI: 10.1007/s10865-022-00306-5.
- Cole RM, Angelotti A, Sparagna GC, Ni A, Belury MA. Linoleic acid-rich oil alters circulating cardiolipin species and fatty acid composition in adults: A randomized controlled trial. Mol Nutr Food Res 2022; 66:e2101132; doi: 10.1002/mnfr.202101132.
- Gumpper-Fedus K, Hart PA, Belury MA, Crowe O, Cole RM, Pita Grisanti V, Badi N, Liva S, Hinton A, Coss C, Ramsey ML, Noonan A, Conwell DL, Cruz-Monserrate Z. Altered plasma fatty acid abundance is associated with cachexia in treatment-naïve pancreatic cancer. Cells 2022; 11(5):910. doi: 10.3390/cells11050910
- Belury MA, Clark BC, McGrath R, Cawthon PM. Linoleic acid intake and physical function: Pilot results from the Health ABC energy expenditure sub-study. Adv Geriatr Med Res 2022; 4(1):e220001. doi: 10.20900/agmr20220001.
- Snoke DB, Nishikawa Y, Cole RM, Ni A, Angelotti A, Vodovotz Y, Belury MA. Dietary naringenin preserves insulin sensitivity and grip strength and attenuates inflammation but accelerates weight loss in a mouse model of cancer cachexia. Mol Nutr Food Res 2021, in press
- Butler MJ, Deems NP, Muscat S, Butt CM, Belury MA, Barrientos RM. Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates. Brain Behav Immun 2021; in press
- Belury MA, Cole RM, Andridge R, Keiter A, Raman SV, Lustberg MB, Kiecolt-Glaser JK. Erythrocyte long chain omega-3 fatty acids are positively associated with lean mass and grip strength in women with recent diagnoses of breast cancer. J Nutr 2021; in press
- Madison, AA, Belury, MA, Andridge, R, Renna, ME, Shrout, MR, Malarkey, WB, Lin, J, Epel, ES, Kiecolt-Glaser, JK. Omega-3 supplementation and stress reactivity of cellular aging biomarkers: An ancillary substudy of a randomized, controlled trial in midlife adults. Mol Psychol 2021; in press
- Cole RM, Puchala S, Ke J-Y, Abdel-Rasoul M, Harlow K, O’Donnell B, Bradley D, Andridge R, Borkowski K, Newman JW, Belury MA. Linoleic acid-rich oil supplementation increases total and high molecular weight adiponectin and alters plasma oxylipins in postmenopausal women with metabolic syndrome. Curr Dev Nutr 2020; 4: doi: 10.1093/cdn/nzaa136
- Madison A, Belury MA, Andridge R, Shrout MR, Renna M, Malarkey W, Bailey M, Kiecolt-Glaser JK. Afternoon distraction: a high saturated fat meal and endotoxemia impact post-meal attention in a randomized crossover trial. Am J Clin Nutr 2020;111: 1150-8
- Banh TH, Puchala SE, Cole RM, Andridge RR, Kiecolt-Glaser JK, Belury MA. Blood level of adiponectin is positively associated with lean mass in women without type 2 diabetes. Menopause 2019; 26: 1311-7
- Angelotti A, Cole RM, Raatz SK, Belury MA. Evaluation of a rapid assessment questionnaire using a biomarker for dietary intake of n-3 fatty acids. Lipids 2019; 54: 321-8
- Banh T, Snoke D, Cole RM, Angelotti A, Schnell PM, Belury MA. Higher tumor mass and lower adipose mass are associated with colon-26 adenocarcinoma-induced cachexia in male, female and ovariectomized mice. Oncol Reports 2018; 41: 2909-18
- Kiecolt-Glaser JK, Wilson SJ, Bailey ML, Andridge R, Peng J, Jaremka LM, Fagundes CP, Malarkey WB, Laskowski B, Belury MA. Marital distress, depression, and a leaky gut: translocation of bacterial endotoxin as a pathway to inflammation. Psychoneuroendocrinology 2018; 98:52-60
