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Research Publications

Mechanistic Research and Preclinical Studies

Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge D, Grotewold E, Doseff AI. Apigenin, a plant flavonoid, inhibits inflammatory cytokines and induces apoptosis in LPS treated human monocyte. In press 2008.

Purushotham A, Liu LF, Wendel AA, Shrode GE, Belury MA. Lack of adipose lowering effect of CLA suppresses hepatic steatosis and stearoyl-CoA desaturase in Wistar rat liver. J Nutr Biochem 2008:In press.

Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD. 2008. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr Cancer. 60 Suppl 1:61-69.

Tomatoes and Tomato Products: Nutritional, Medicinal, and Therapeutic Properties. In press; 2008. Grainger EM, Canene-Adams K, Erdman JW,Jr, Clinton SK. Tomatoes and components as modulators of experimental prostate carcinogenesis.

Duncan FJ, Martin JR, Wulff BC, Stoner GD, Tober KL, Oberyszyn TM, Kusewitt DF, Van Buskirk AM. 2009. Topical Treatment with Black Raspberry Extract Reduces Cutaneous UVB-Induced Carcinogenesis and Inflammation. Cancer Prevention Research. 2(7):665-672.

Purushotham A, Tian M, Belury MA. 2009. The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells. Molecular Nutrition & Food Research. 53(2):300-307.

Raghavamenon A, Garelnabi M, Babu S, Aldrich A, Litvinov D, Parthasarathy S. 2009. alpha-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling. 11(6):1237-1248.

Li YY, Zhang T, Schwartz SJ, Sun DX. 2009. New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential. Drug Resist. Update. 12(1-2):17-27.

Dworkin AM, Tober KL, Duncan FJ, Yu LB, VanBuskirk AM, Oberyszyn TM, Tolland AE. 2009. Chromosomal Aberrations in UVB-Induced Tumors of Immunosuppressed Mice. Genes Chromosomes & Cancer. 48(6):490-501.

Martin J, Duncan FJ, Keiser T, Shin S, Kusewitt DF, Oberyszyn T, Satoskar AR, VanBuskirk AM. 2009. Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet-B (UVB) -induced nonmelanoma skin cancer (NMSC). Faseb J. 23(3):720-730.

Benavides F, Oberyszyn TM, VanBuskirk AM, Reeve VE, Kusewitt DF. The hairless mouse in skin research. Journal of Dermatological Science. Jan 2009;53(1):10-18.

Gonzalez-Mejia ME, Doseff AI. Regulation of monocytes and macrophages cell fate. Frontiers in Bioscience. Jan 2009;14:2413-2431.

Wang XY, Colby JKL, Rengel RC, Fischer SM, Clinton SK, Klein RD. Overexpression of Cyclooxygenase-2 (COX-2) in the Mouse Urinary Bladder Induces the Expression of Immune- and Cell Proliferation-Related Genes. Molecular Carcinogenesis. Jan 2009;48(1):1-13.

Jing P, Bomser JA, Schwartz SJ, He J, Magnuson BA, Giusti MM. Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. J Agric Food Chem. 2008 Oct; 56(20):9391-98.

Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF. Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res. 2008 Aug;68(15):6460-6467.

During A, Doraiswamy S, Harrison EH. Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. J Lipid Res 2008 Aug;49(8):1715-24.

Steinhour E, Sherwani SI, Mazerik JN, Ciapala V, O'Connor Butler E, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A(2), lipoxygenase, and cyclooxygenase. Mol Cell Biochem 2008 Aug;315(1-2):97-112.

Mallery SR, Zwick JC, Pei P, Tong M, Larsen PE, Shumway BS, Lu B, Fields HW, Mumper RJ, Stoner GD. Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res. 2008 Jun;68(12):4945-4957.

Powolny AA, Wang SH, Carlton PS, Hoot DR, Clinton SK. Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats. Mol Carcinog 2008 Jun;47(6):458-65.

Shumway BS, Kresty LA, Larsen PE, Zwick JC, Lu B, Fields HW, Mumper RJ, Stoner GD, Mallery SR. Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin.Cancer Res. Apr 15 2008;14(8):2421-2430.

Brophy LT, Litvinov D, Parthasarathy S. Potential modulation of cholesterol homeostasis by sesamol [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E127.

Brophy LT, Selvarajan K, Jaichander P, Parthasarathy S. Atheroprotective role of sesamol: Modulation of the lipid profile [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E59.

Litvinov D, Garelnabi MO, Parthasarathy S. Lipid peroxide decomposition product azelaic acid may promote calcification in atherosclerosis [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E84.

Tulio AZ, Reese RN, Wyzgoski FJ, Rinaldi PL, Fu R, Scheerens JC, Miller AR. Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. J Agric Food Chem 2008 Mar;56(6):1880-8.

Wulff BC, Schick JS, Thomas-Ahner JM, Kusewitt DF, Yarosh DB, Oberyszyn TM. Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis. Photochem Photobiol 2008 Mar;84(2):317-21.

Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. Jan 2008;49(1):98-106.

Albrecht DS, Clubbs EA, Ferruzzi M, Bomser JA. Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation. Chem Biol Interact 2008 Jan;171(1):89-95.

Li J, Zhang D, Stoner GD, Huang C. Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog 2008 Apr;47(4):286-94.

Oonsivilai R, Cheng C, Bomser J, Ferruzzi MG, Ningsanond S. Phytochemical profiling and phase II enzyme-inducing properties of Thunbergia laurifolia Lindl. (RC) extracts. J Ethnopharmacol 2007 Dec;114(3):300-6.

Parthasarathy S, Babu S. Alpha-keto acids prevent the breakdown of lipid peroxides: Potential therapeutic value in diabetes [Abstract]. In: Free Rad Biol Med; Nov; New York, NY: Elsevier Science Inc.; 2007. p. S105.

Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E, Doseff AI. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol 2007 Nov;179(10):7121-7. Abstract

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem 2007 Aug;18(8):525-32. Abstract

Tober KL, Thomas-Ahner JM, Maruyama T, Oberyszyn TM. Possible cross-regulation of the E prostanoid receptors. Mol Carcinog 2007 Aug;46(8):711-5.

Voss OH, Batra S, Kolattukudy SJ, Gonzalez-Mejia ME, Smith JB, Doseff AI. Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J Biol Chem 2007 Aug;282(34):25088-99.

Trasino SE, Harrison EH, Wang TT. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood) 2007 Jun;232(6):762-71. Abstract

Huang C, Zhang D, Li J, Tong Q, Stoner GD. Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries. Nutr Cancer 2007 Jul;58(2):205-12.

Reen RK, Dombkowski AA, Kresty LA, Cukovic D, Mele JM, Salagrama S, Nines R, Stoner GD. Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 2007 Jul;67(13):6484-92.

Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X, Chen CS. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicol Pathol 2007;35(4):549-61.

Linke T, Doraiswamy S, Harrison EH. Rat plasma proteomics: effects of abundant protein depletion on proteomic analysis. J Chromatogr B Analyt Technol Biomed Life Sci 2007 Apr;849(1-2):273-81.

Mallery SR, Stoner GD, Larsen PE, Fields HW, Rodrigo KA, Schwartz SJ, Tian Q, Dai J, Mumper RJ. Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention. Pharm Res 2007 Apr;24(4):728-37.

Zhou XD, Smith AM, Failla ML. Estrogen status alters tissue distribution of oral dose of Se-75-selenite and liver mRNA levels of SelP and GPx [Abstract]. In: FASEB J; Apr; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A717.

Long AC, Colitz CMH, Bomser JA. Regulation of gap junction intercellular communication in primary canine lens epithelial cells: Role of protein kinase C. Current Eye Res 2007 Mar;32(3):223-31.

Belury MA, Kavanaugh CJ, Liu KL. Conjugated linoleic acid modulates phorbol ester-induced PPARdelta and K-FABP mRNA expression in mouse skin. Nutr Res 2007;27(1):48-55. Abstract

Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW,Jr. Combinations of tomato and broccoli enhance antitumor activity in Dunning R3327-H prostate adenocarcinomas. Cancer Res 2007 Jan;67(2):836-43.

Higashi Y, Sukhanov S, Parthasarathy S, Delafontaine P. Oxidized low-density lipoprotein down-regulates insulin-like growth factor 1 receptor via enhanced generation of nitric oxide and reactive oxygen species in human aortic smooth muscle cells [Abstract]. In: J Investigative Med; Jan; Hamilton, Ontario: BC Deckter Inc; 2007. p. S247.

Tober KL, Thomas-Ahner JM, Kusewitt DF, Oberyszyn TM. Effects of UVB on E prostanoid receptor expression in murine skin. J Invest Dermatol 2007 Jan;127(1):214-21.

Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury MA, Adams LS, Williams D. Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 2006 Dec;66(24):12026-34. Abstract

Guo Y, Wang S, Hoot DR, Clinton SK. Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biochem 2006 Dec;18(6):408-17. Abstract

Hwang H, Chen T, Nines RG, Shin HC, Stoner GD. Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols. Int J Cancer 2006 Dec;119(12):2742-9.

Chen T, Rose ME, Hwang H, Nines RG, Stoner GD. Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. Carcinogenesis 2006 Nov;27(11):2301-7.

Yu BN, Parthasarathy S, Santanam N. The effect of oxidized linoleic acid feeding on liver PPAR related gene expression in C57BL/6J mice [Abstract]. In: Free Rad Biol Med; Nov; New York, NY: Elsevier Science Inc; 2006. p. S143.

Vargo MA, Voss OH, Poustka F, Cardounel AJ, Grotewold E, Doseff AI. Apigenin-induced apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 2006 Sep;72(6):681-92.

Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis 2006 Aug;27(8):1617-26.

Rodrigo KA, Rawal Y, Renner RJ, Schwartz SJ, Tian Q, Larsen PE, Mallery SR. Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 2006 Apr;54(1):58-68. Abstract

Chen T, Hwang H, Rose ME, Nines RG, Stoner GD. Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res 2006 Mar;66(5):2853-9.

Chitchumroonchokchai C, Failla ML. Inhibition of lipid peroxidation and stress signaling by synergistic antioxidant nutrients in human lens epithelial cells [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A1015.

Clubbs EA, Bomser JA. Isoflavone-induced activation of extracellular signal-regulated kinase (ERK 1/2) in non-tumorigenic prostate epithelial cells [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A1014.

Oonsivilai R, Cheng C, Ningsanond S, Bomser JA, Ferruzzi MG. Induction of quinone reductase activity in marine hepatoma cells by extracts of Thunbergia laurifolia Lindl [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A154.

Wang X, Clubbs EA, Bomser JA. Genistein modulates prostate epithelial cell proliferation via estrogen- and extracellular signal-regulated kinase-dependent pathways. J Nutr Biochem 2006 Mar;17(3):204-10.

Bhaskaran S, Santanam N, Penumetcha M, Parthasarathy S. Inhibition of atherosclerosis in low-density lipoprotein receptor-negative mice by sesame oil. J Med Food 2006 Jan;9(4):487-90.

Huang C, Li J, Song L, Zhang D, Tong Q, Ding M, Bowman L, Aziz R, Stoner GD. Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res 2006 Jan;66(1):581-7.

Lu H, Li J, Zhang D, Stoner GD, Huang C. Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes. Nutr Cancer 2006 Jan;54(1):69-78.

Reen RK, Nines R, Stoner GD. Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats. Nutr Cancer 2006 Jan;54(1):47-57.

Stoner GD, Chen T, Kresty LA, Aziz R, Reinemann T, Nines R. Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer 2006 Jan;54(1):33-46.

Zikri NN, Hecht SS, Carmella SG, Auer H, Chen T, Stoner GD. Effects of black raspberry components on growth and gene expression in rat esophageal epithelial cells [Abstract]. In: Cancer Epidemiol;Biomarkers Prev; Nov; Philadelphia, PA: Amer Assoc Cancer Research; 2005. p. 2751S.

Yee LD, Young DC, Rosol TJ, Vanbuskirk AM, Clinton SK. Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPAR gamma ligand rosiglitazone. J Nutr 2005 Jan;135(5):983-8.

Gu YH, Belury MA. Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes. Cancer Lett 2005 Mar;220(1):21-8. Abstract

Mertens-Talcott SU, Bomser JA, Romero C, Talcott ST, Percival SS. Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. J Nutr 2005 Mar;135(3):609-14.

Han C, Ding H, Casto B, Stoner GD, D'Ambrosio SM. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 2005 Mar;51(2):207-17.

Hudson TS, Stoner GD, Morse MA, Young H, Mallery SR. Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. Toxicol Lett 2005 Mar;155(3):427-36.

King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005 Jan;151(2):143-9.