The Ohio State University

• Help
• Campus Map
• Find People

Research Publications

Digestion, Absorption, and Bioavailability

Walsh KR, Failla ML. 2009. Transport and metabolism of equol by Caco-2 human intestinal cells. J Agric Food Chem. 57(18):8297-8302.

Bumrungpert A, Kalpravidh RW, Suksamrarn S, Chaivisuthangkura A, Chitchumroonchokchai C, Failla ML. 2009. Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells. Mol Nutr Food Res. 53 Suppl 1:S54-61.

He J, Wallace TC, Keatley KE, Failla ML, Giusti MM. 2009. Stability of Black Raspberry Anthocyanins in the Digestive Tract Lumen and Transport Efficiency into Gastric and Small Intestinal Tissues in the Rat. Journal of Agricultural and Food Chemistry. 57(8):3141-3148.

Thakkar SK, Huo TY, Maziya-Dixon B, Failla ML. 2009. Impact of Style of Processing on Retention and Bioaccesibility of beta-Carotene in Cassava (Manihot esculanta, Crantz). Journal of Agricultural and Food Chemistry. 57(4):1344-1348.

Walsh KR, Haak SJ, Fastinger ND, Bohn T, Tian QG, Mahan DC, Schwartz SJ, Failla ML. 2009. Gastrointestinal absorption and metabolism of soy isoflavonoids in ileall-canulated swine. Mol. Nutr. Food Res. 53(2):277-286.

Mills JP, Tumuhimbise GA, Jamil KM, Thakkar SK, Failla ML, Tanumihardjo SA. Sweet Potato beta-Carotene Bioefficacy Is Enhanced by Dietary Fat and Not Reduced by Soluble Fiber Intake in Mongolian Gerbils. Journal of Nutrition. Jan 2009;139(1):44-50

Thakkar SK, Failla ML. Bioaccessibility of Pro-Vitamin A Carotenoids Is Minimally Affected by Non Pro-Vitamin A Xanthophylls in Maize (Zea mays sp.). Journal of Agricultural and Food Chemistry. Dec 2008;56(23):11441-11446.

Failla ML, Chitchumroonchokchai C, Ishida B. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J Nutr 2008 Mar;138(3):482-6.

Failla ML, Huo T, Thakkar SK. In vitro screening of relative bioaccessibility of carotenoids from foods. Asian Pacific J Clin Nutr 2008;17(S1):200-3.

Ornelas-Paz JD, Failla ML, Yahia EM, Gardea-Bejar A. Impact of the stage of ripening and dietary fat on in vitro bioaccessibility of beta-carotene in 'Ataulfo' mango. J Agric Food Chem 2008 Feb;56(4):1511-6. Abstract

During A, Harrison EH. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res 2007 Oct;48(10):2283-94.

Huo T, Ferruzzi MG, Schwartz SJ, Failla ML. Impact of fatty acyl composition and quantity of triglycerides on bioaccessibility of dietary carotenoids. J Agric Food Chem 2007 Oct;55(22):8950-7.

Thakkar SK, Maziya-Dixon B, Dixon AG, Failla ML. Beta-carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to beta-carotene content in different genotypes of cassava. J Nutr 2007 Oct;137(10):2229-33.

During A, Harrison EH. Retinol secretion at the basolateral side of Caco-2 cells is saturable: possible ABCA1 implication [Abstract]. In: Annals Nutr Metabol, Basel, Switzerland: Karger, Allschwilerstrasse; 2007. p. 211-2.

During A, Harrison EH. Retinol uptake and secretion in Caco-2 cells: possible role of ABCA1 [Abstract]. In: Annals Nutr Metabol, Basel, Switzerland: Karger, Allschwilerstrasse; 2007. p. 212.

Unlu NZ, Bohn T, Francis DM, Nagaraja HN, Clinton SK, Schwartz SJ. Lycopene from heat induced cis-isomer rich tomato pasta sauce is more bioavailable than from all-trans rich pasta sauce in humans. Br J Cancer 2007 Jul;98(1):140-6. Abstract

Huo T, Ferruzzi M, Schwartz SJ, Failla ML. Impact of trigacylglyceride structure on micellarization and intestinal cell uptake of dietary carotenoids [Abstract]. In: IFT Annual Mtg Tech Program; Jul; Chicago, IL: Institute of Food Technologists; 2007. p. 010-14.

Thakkar SK, Failla ML. In vitro screening of β-carotene bioavailability from cassava genotypes using the coupled digestion/CaCo-2 cell model [Abstract]. In: IFT Annual Mtg Tech Program; Jul; Chicago, IL: Institute of Food Technologists; 2007. p. 146-36.

Pullakhandam R, Failla ML. Micellarization and intestinal cell uptake of b-carotene and lutein from drumstick (Moringa oleifera) leaves. J Medicinal Foods 2007 Jun;10(2):252-7.

Huo T, Ferruzzi MG, Belury MA, Schwartz SJ, Failla ML. Impact of amount and triglyceride (TG) structure on micellarization of dietary carotenoids during simulated digestion [Abstract]. In: FASEB J; Apr; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A730-1.

Kohut AR, Failla ML, Watkins BA, Ferruzzi MG. The impact of lipid quantity and type of carotenoid bioaccessibility from vegetables [Abstract]. In: FASEB J; Apr; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A350.

Neilson AP, Hopf A, Cooper BR, Bomser JA, Ferruzzi MG. Catechin degradation and concurrent formation of homo- and hetero-catechin dimers during simluated digestion [Abstract]. In: FASEB J; Apr; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A110.

Walsh KR, Haak SJ, Bohn T, Tian Q, Schwartz SJ, Failla ML. Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies. Am J Clin Nutr 2007 Apr;85(4):1050-6.

Bhagavan HN, Chopra RK, Craft NE, Chitchumroonchokchai C, Failla ML. Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. Int J Pharm 2007 Mar;333(1-2):112-7. Abstract

Unlu NZ, Bohn T, Francis DM, Clinton SK, Schwartz SJ. Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes. J Agric Food Chem 2007 Feb;55(4):1597-603. Abstract

Bohn T, Tian Q, Chitchumroonchokchai C, Failla ML, Schwartz SJ, Cotter R, Waksman JA. Supplementation of test meals with fat-free phytosterol products can reduce cholesterol micellarization during simulated digestion and cholesterol accumulation by Caco-2 cells. J Agric Food Chem 2007 Jan;55(2):267-72. Abstract

Barret KE, Ghishan FK, Merchant JL, Said HM, Wood JD, Johnson LR, editors. Physiology of the Gastrointestinal Tract. Fourth ed. Academic Press; 2006. During A, Harrison EH. Digestion and intestinal absorption of dietary carotenoids and vitamin A.

Ferruzzi MG, Lumpkin JL, Schwartz SJ, Failla ML. Digestive stability, micellarization, and uptake of beta-carotene isomers by Caco-2 human intestinal cells. J Agric Food Chem 2006 Apr;54(7):2780-5.

He J, Magnuson BA, Lala G, Tian Q, Schwartz SJ, Giusti MM. Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation. Nutr Cancer 2006 Apr;54(1):3-12. Abstract

Chitchumroonchokchai C, Failla ML. Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells. J Nutr 2006 Mar;136(3):588-94. Abstract

Tian Q, Giusti MM, Stoner GD, Schwartz SJ. Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J Agric Food Chem 2006 Feb;54(4):1467-72. Abstract

Failla ML. Coupled in vitro digestion/Caco2 intestinal cell model for screening the relative bioavailability of carotenoids from foods and supplements. Proceedings of 2005 International Symposium on Nutraceuticals and Food Safety for Well-being Life; YongPyong, Korea. 2005. p. 14-22.

Failla ML, Chitchumroonchokchai C. In vitro models as tools for screening the relative bioavailabilities of provitamin A carotenoids in foods [Internet]. Washington DC: HarvestPlus; 2005. 36 p. HarvestPlus Technical Monograph Series #3. Available from: www.harvestplus.org/pubs.html.

Schwartz SJ. How can the metabolomic response to lycopene (exposures, durations, intracellular concentrations) in humans be adequately evaluated? J Nutr 2005;135(8):2040S-1S.

Schwartz SJ. Absorption and bioavailability of carotenoids [Meeting Abstract]. Papers of the Amer Chem Society 230; Washington, DC. Washington, DC: American Chemical Society; 2005. p. U63-4.

Unlu NZ, Bohn T, Clinton SK, Schwartz SJ. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutr 2005;135(3):431-6.

Walsh KR, Haak SJ, Bohn T, Fastinger ND, Tian Q, Mahan D, Schwartz SJ, Failla ML. Roles of the small and large intestines in the absorption and metabolism of soy isoflavonoids [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2005. p. A415.